Author

C. M. Kobras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

A. H. van Vliet· 1 shared A. J. Baldwin· 1 shared A. J. Taylor· 1 shared A. Sim· 1 shared A. Turner· 1 shared B. G. Davis· 1 shared B. Pascoe· 1 shared C. J. Buchanan· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperMicrobiology

A. H. van Vliet

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Author profile →

3 papers

Recent·Most cited

Haptenic adducts of beta-lactam antibiotics elicit antibody responses with narrow clonality and specificity

L. P. Deimel, L. Moynie, G. Sun, V. Lewis, A. Turner, C. J. Buchanan, S. A. Burnap, C. M. Kobras, M. Stracy, W. B. Struwe, A. J. Baldwin, J. Naismith, B. G. Davis, Q. J. Sattentau

This study investigates how penicillin G forms immunogenic adducts on proteins and elicits specific antibody responses in mice, revealing clonal dominance and limited cross-reactivity with other beta-lactam antibiotics.

bioRxiv · Nov 2, 2023 · PreprintImmunology

A two-hit epistasis model prevents core genome disharmony in recombining bacteria

A. J. Taylor, K. Yahara, B. Pascoe, L. Mageiros, E. Mourkas, J. K. Calland, S. Puranen, M. D. Hitchings, K. A. Jolley, C. M. Kobras, S. C. Bayliss, N. J. Williams, A. H. van Vliet, J. Parkhill, M. C. Maiden, , S. K. Sheppard

The paper shows that recombination in bacteria can overcome genomic disharmony through a two-hit epistasis model, allowing beneficial gene combinations to be reinstated in new genetic backgrounds.

bioRxiv · Mar 15, 2021 · PreprintMicrobiology

BceAB-type antibiotic resistance transporters appear to act by target protection of cell wall synthesis

C. M. Kobras, H. Piepenbreier, J. Emenegger, A. Sim, G. Fritz, S. Gebhard

This study investigates the mechanism of BceAB-type transporters in Bacillus subtilis, showing they protect cell wall synthesis by freeing lipid II intermediates from antibiotic inhibition.

bioRxiv · Nov 11, 2019Microbiology