Modulating pathogenesis with Mobile-CRISPRi
O. Rosenberg, J.-X. Qu, N. K. Prasad, J. Peters, M. Looney, M. Yu, A. Lyden, S. Chen, E. Crawford, M. Silvis
The paper demonstrates the use of Mobile-CRISPRi to knock down virulence life-style genes in a murine infection model, showing reduced virulence in mice.
bioRxiv · Apr 25, 2019Microbiology