O. Rosenberg

How Mycobacterium tuberculosis builds a home: Single-cell analysis reveals M. tuberculosis ESX-1-mediated accumulation of anti-inflammatory macrophages in infected mouse lungs.

This study uses single-cell RNA sequencing to show that M. tuberculosis ESX-1 promotes the recruitment and differentiation of anti-inflammatory macrophages in infected mouse lungs.

Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from FDG yield potent sensors of living bacteria in vivo

This paper develops chemoenzymatic methods to synthesize [18F]-labeled disaccharides from FDG, which detect bacteria in vivo by their specific glycan incorporation.

Cyclic gallium-68 labeled peptides for specific detection of human angiotensin-converting enzyme 2

This paper develops 68Ga-labeled cyclic peptides derived from ACE2 inhibitor DX600 to detect ACE2 expression in vivo, showing specific binding in organs affected by SARS-CoV-2.

Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity

This study investigates the interaction between SARS-CoV-2 Spike and ACE2, showing that dimeric ACE2 binds with high affinity to Spike and blocks viral entry, with limited intra-Spike avidity.

A large inner membrane pore defines the ESX translocon

The paper reports the cryo-EM structure of the ESX-3 secretion system, revealing a large pore capable of translocating folded substrates and a regulatory cytoplasmic complex.

Modulating pathogenesis with Mobile-CRISPRi

The paper demonstrates the use of Mobile-CRISPRi to knock down virulence life-style genes in a murine infection model, showing reduced virulence in mice.

Two accessory proteins govern MmpL3 mycolic acid transport in mycobacteria

This study identifies two new proteins involved in the MmpL3-mediated mycolic acid transport in mycobacteria, revealing their roles in transport and stress response.

Determination of biophysical parameters for enhancement of human osteoblast proliferation by mechanical vibration in the infrasonic frequency range

This study identifies optimal mechanical vibration parameters (50-70 Hz) to enhance human osteoblast proliferation in vitro by reducing cell death and maturation levels.