Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue
G. Chen, Y. Andrade-Talavera, X. Zhong, S. Hassan, H. Biverstal, H. Poska, A. Abelein, A. Leppert, N. Kronqvist, A. Rising, H. Hebert, P. J.B. Koeck, A. Fisahn, J. Johansson
The paper shows that a conserved Asp residue in BRICHOS domains is critical for inhibiting amyloid toxicity but not amorphous aggregation, with pH sensitivity and evolutionary conservation.
bioRxiv · Dec 1, 2021 · PreprintBiochemistry