X. Zhong

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Predicting the macrovascular contribution to resting-state fMRI functional connectivity at 3 Tesla: A model-informed approach

This paper demonstrates the feasibility of predicting resting-state fMRI functional connectivity and BOLD fluctuation amplitudes using biophysical models of macrovascular anatomy at 3 Tesla.

Multiplexed Short-wave Infrared Imaging Highlights Anatomical Structures in Mice

This study develops three-color SWIR quantum dot imaging in mice to visualize lymphatic and vascular networks with high resolution and multiplexing capability.

A General-Purpose Non-invasive Neurotechnology Research Platform

The paper introduces a non-invasive neurotechnology platform with multi-modal sensors and integration into BCI2000, demonstrating its use in sleep monitoring and evoked potentials.

De novo design of drug-binding proteins with predictable binding energy and specificity

This paper designs drug-binding proteins with low nanomolar affinity and predictable specificity using computational methods, validated by experimental measurements and structural analysis.

Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.

This study identifies Lrp10 as a negative regulator of CD8 T cell homeostasis and tumor resistance by suppressing IL7R levels and enhancing anti-tumor immunity.

CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex

This paper shows that CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex capable of synthesizing cellulose in vitro.

Coordination of focal adhesion nanostructure and mechano-signaling drives cardiomyocyte differentiation

This study identifies BNIP-2 as a key organizer of focal adhesion nanostructure that enhances signaling and traction force, essential for cardiomyocyte differentiation.

Assessment of the macrovascular contribution to resting-state fMRI functional connectivity at 3 Tesla

This study assesses the macrovascular contribution to resting-state fMRI functional connectivity, finding strong correlations between large veins and arteries and demonstrating their significant impact on whole-GM connectivity.

TRAF6 initiates inflammatory signaling via organizing membraneless cytoplasmic condensates

This study shows TRAF6 initiates inflammatory signaling by forming membraneless condensates through phase separation, which activates NF-κB signaling.

In vivo Ontogeny of human forebrain neural progenitor cell grafts in adult rats: an immunohistological study

This study tracks human neural progenitor cell grafts in adult rats up to 9 months, revealing their migration and differentiation patterns, and highlights their potential for neural repair.

Gemcitabine plus nab-paclitaxel preserves skeletal and cardiac mass and function in a murine model of pancreatic cancer cachexia

This study shows that gemcitabine plus nab-paclitaxel reduces tumor burden and prevents muscle and cardiac wasting in a murine model of pancreatic cancer cachexia.

Comparative genomic analysis between Leonurus japonicus and Leonurus sibiricus

This study reports chromosome-level genome sequences of two Leonurus species, providing resources for studying bioactive molecules in medicinal plants.

Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.

This study introduces disulfides into SARS-CoV-1 spike protein to stabilize locked conformations, revealing conserved structural features with SARS-CoV-2.

Brevicidine, a bacterial non-ribosomally produced cyclic antimicrobial lipopeptide with a unique modus operandi

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

Glutamine is essential for overcoming theimmunosuppressive microenvironment in malignant salivary gland tumors

This study shows that dietary glutamine supplementation enhances antitumor immunity by altering the tumor microenvironment in mice with malignant salivary gland tumors.

Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue

The paper shows that a conserved Asp residue in BRICHOS domains is critical for inhibiting amyloid toxicity but not amorphous aggregation, with pH sensitivity and evolutionary conservation.

Role for a lytic polysaccharide monooxygenase in cell wall remodelling

The paper identifies two enzymes, CslZ and LpmP, involved in apical glycan deposition in Streptomycetes by remodeling peptidoglycan.

A MYB transcription factor, PlMYB308, plays an essential role in flower senescence of herbaceous peony

This study identifies PlMYB308 as a key regulator of flower senescence in herbaceous peony by modulating hormone levels and anthocyanin biosynthesis.

Individual cell-based modeling of tumor cell plasticity-induced immune escape after CAR-T therapy

The paper develops a computational model to simulate tumor cell plasticity and immune escape after CAR-T therapy, finding that CAR-T stress induces tumor cells to transition into hematopoietic stem-like and myeloid-like cells, leading to relapse.

CsrA-controlled proteins reveal new dimensions of Acinetobacter baumannii desiccation tolerance

This study identifies CsrA-controlled proteins in A. baumannii that contribute to desiccation tolerance, revealing novel mechanisms involving proteins of unknown function and intrinsically disordered proteins.

Amplification-free detection of viral RNA by super resolution imaging-based CRISPR/Cas13a System

This paper develops a CRISPR/Cas13a system combined with super resolution imaging for direct, amplification-free viral RNA detection with improved sensitivity.

A spindle and thread-mechanism unblocks translation of N-terminally disordered proteins

This study shows that fusing disordered proteins to an engineered spider silk domain improves their translation efficiency and activity in cells.

rtcisE2F drives liver TIC self-renewal and metastasis via m6A-modulated mRNA stability of E2F6 and E2F3

This paper identifies rtcisE2F as a circRNA that regulates liver TIC self-renewal and metastasis by modulating E2F6 and E2F3 mRNA stability through m6A reader interactions.

Comparative genomic analyses provide clues to capsule switch in Streptococcus suis

This study identifies capsule switch in Streptococcus suis strains through comparative genomic analyses, revealing genetic exchange between SS2, SS3, and SS7 strains.

Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

Substrate deformation regulates DRM2-mediated DNA methylation in plants

This study identifies DNA deformation as a mechanism regulating DRM2-mediated methylation specificity in plants, showing how substrate deformation influences substrate preference.

LncRNA MIR4435-2HG mediates cisplatin resistance in HCT116 cells by regulating Nrf2 and HO-1

This study identifies LncRNA MIR4435-2HG as a mediator of cisplatin resistance in HCT116 cells via the Nrf2/HO-1 pathway.

The systemic activin response to pancreatic cancer: Implications for effective cancer cachexia therapy

This study shows that pancreatic cancer induces a systemic activin response contributing to cachexia, and that targeting both tumor and host-derived activins may improve therapy.

Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing

This study establishes a method to expand primary cells from salivary gland neoplasms for genetic and chemosensitivity testing, identifying therapeutic targets and resistance mechanisms.