HIV-1 Protease Uses Bi-Specific S2/S2’ Subsites To Optimize Cleavage of Two Classes of Target Sites
M. Potempa, S.-K. Lee, N. KurtYilmaz, E. A. Nalivaika, A. Rogers, E. Spielvogel, C. W. Carter, C. A. Schiffer, R. Swanstrom
This study shows HIV-1 protease uses bi-specific S2/S2’ subsites to cleave two classes of target sites, with distinct interactions based on the presence or absence of a P1 proline.
bioRxiv · Aug 29, 2018Biochemistry