Author

E. Spielvogel

Primary ORCID profile (0000-0002-4562-789X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

E. SpielvogeliD1 paper · University of North Carolina at Chapel Hill

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

C. A. Schiffer· 2 shared R. Swanstrom· 2 shared S.-K. Lee· 2 shared A. Ali· 1 shared A. Rogers· 1 shared A. Sondgeroth· 1 shared C. W. Carter· 1 shared E. A. Nalivaika· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

C. A. Schiffer

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2 papers

Recent·Most cited

Selection of HIV-1 for Resistance to Fifth Generation Protease Inhibitors Reveals Two Independent Pathways to High-Level Resistance

E. Spielvogel, S.-K. Lee, S. Zhou, G. J. Lockbaum, M. Henes, A. Sondgeroth, K. Kosovrasti, E. Nalivaika, A. Ali, N. K. Yilmaz, C. A. Schiffer, R. Swanstrom

This study identifies two independent resistance pathways to fifth-generation protease inhibitors in HIV-1 by analyzing mutations under high drug concentrations.

bioRxiv · Jun 23, 2022Microbiology

HIV-1 Protease Uses Bi-Specific S2/S2’ Subsites To Optimize Cleavage of Two Classes of Target Sites

M. Potempa, S.-K. Lee, N. KurtYilmaz, E. A. Nalivaika, A. Rogers, E. Spielvogel, C. W. Carter, C. A. Schiffer, R. Swanstrom

This study shows HIV-1 protease uses bi-specific S2/S2’ subsites to cleave two classes of target sites, with distinct interactions based on the presence or absence of a P1 proline.

bioRxiv · Aug 29, 2018Biochemistry