Charge-Altering Releasable Transporters enable specific phenotypic manipulation of resting primary natural killer cells
A. J. Wilk, N. L. Benner, R. Vergara, O. A. W. Haabeth, R. Levy, R. M. Waymouth, P. A. Wender, C. A. Blish
This study introduces CARTs, a non-viral transfection method for primary human NK cells, enabling efficient mRNA delivery without activation, preserving phenotype and function, and demonstrating therapeutic potential.
bioRxiv · Feb 28, 2020Immunology