C. A. Blish

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

The paper identifies conserved antiviral pathways across macaques and humans using transcriptomic data from viral infections, showing shared and virus-specific responses that inform pandemic preparedness.

Persistence and Free Chlorine Disinfection of Human Coronaviruses and Their Surrogates in Water

This study evaluates the persistence and chlorine disinfection of human coronaviruses and their surrogates in water, finding varying decay rates and inactivation efficiencies.

NK cell-monocyte crosstalk underlies NK cell activation in severe COVID-19

This study identifies NK cell-monocyte interactions as a driver of NK cell activation and dysfunction in severe COVID-19 through computational and in vitro experiments.

Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality.

This study shows that HIV/ARV-exposed uninfected infants have reduced T cell receptor diversity and altered immune development, increasing infection risk.

Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection

This study identifies pro-inflammatory feedback loops in immune responses to pathogenic lentivirus infection, showing that highly pathogenic variants induce delayed, sustained, and amplifying inflammatory circuits.

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

This study shows SARS-CoV-2 evades NK cell killing by downregulating NKG2D ligands via Nsp1, reducing NK cell cytotoxicity against infected cells.

Disease diagnostics using machine learning of immune receptors

The paper develops Mal-ID, a machine learning framework using immune receptor data to diagnose diseases, detecting infections, autoimmune disorders, and vaccine responses.

Comparative analysis of cell-cell communication at single-cell resolution

This paper introduces Scriabin, a framework for analyzing cell-cell communication at single-cell resolution, validating its findings through multiple experimental approaches and demonstrating its application in uncovering communication pathways in health and disease.

Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells from HIV+ Controllers and Non-Controllers

This study compares T and NK cell phenotypes in blood and lymph nodes of HIV+ controllers and ART-treated individuals, finding distinct cellular features in lymphoid tissues.

SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19

This study shows SARS-CoV-2 infects human adipose tissue, causing inflammation linked to severe COVID-19 outcomes in obese individuals.

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

This study shows that the B.1.427/1.429 (epsilon) SARS-CoV-2 variants cause more severe disease and higher viral loads in the upper respiratory tract in Syrian hamsters compared to the ancestral B.1 (614G) strain.

An intranasal ASO therapeutic targeting SARS-CoV-2

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

Stereotypic expansion of Tregulatory and Th17 cells during infancy is disrupted by HIV exposure and gut epithelial damage.

The paper examines Treg and Th17 cell dynamics in infants, finding HIV exposure disrupts their stereotypic expansion and correlates with gut damage.

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

Single-cell multi-omic profiling identifies immune dysregulation in severe COVID-19, including neutrophil hyperactivation and anti-inflammatory monocytes.

Additional analyses exploring the hypothesized transdifferentiation of plasmablasts to developing neutrophils in severe COVID-19

The paper responds to criticisms of a previous study on transdifferentiation of plasmablasts to neutrophils in severe COVID-19 using single-cell transcriptomic data.

Mass cytometry analysis of the NK cell receptor-ligand repertoire reveals unique differences between dengue-infected children and adults

This study uses mass cytometry to compare NK cell receptor-ligand profiles between dengue-infected children and adults, identifying distinct immune signatures associated with infection outcomes.

Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

This paper develops a feeder-free organoid culture system for human distal lung progenitors and demonstrates SARS-CoV-2 infection of club cells in a novel in vitro model.

Treated HIV Infection Alters Phenotype But Not HIV-specific Function of Peripheral Blood Natural Killer Cells

This study examines how treated HIV infection affects NK cell phenotype and function, finding altered repertoires but no increased HIV-specificity.

Charge-Altering Releasable Transporters enable specific phenotypic manipulation of resting primary natural killer cells

This study introduces CARTs, a non-viral transfection method for primary human NK cells, enabling efficient mRNA delivery without activation, preserving phenotype and function, and demonstrating therapeutic potential.

Characterization of the impact of daclizumab beta on circulating natural killer cells by mass cytometry

This study uses mass cytometry to analyze how daclizumab beta affects NK cell phenotypes in RMS patients, showing distinct changes in CD56bright and CD56dim subsets.

TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells

This study shows that TIGIT is upregulated on NK cells in untreated HIV+ individuals and marks a functional, mature NK cell subset with enhanced responses to HIV-infected targets.

Enhancing natural killer cell function with gp41-targeting bispecific antibodies to combat HIV infection

This study develops bispecific antibodies targeting HIV gp41 and NK cell CD16 to enhance ADCC against HIV-infected cells, showing improved degranulation and killing of infected targets.

HLA upregulation during dengue virus infection suppresses the natural killer cell response

This study shows that HLA class I upregulation during dengue virus infection suppresses natural killer cell activity, potentially contributing to disease progression.