Author

R. Vergara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Assay:flow cytometry· 2 Assay:protein structure· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

C. A. Blish· 4 shared A. B. Arauz· 2 shared D. Beltran· 2 shared D.-A. Silva· 2 shared J. L. McKechnie· 2 shared L. Saenz· 2 shared S. Holmes· 2 shared S. Lopez-Verges· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersImmunology

C. A. Blish

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Cross-species transmission and PB2 mammalian adaptations of highly pathogenic avian influenza A/H5N1 viruses in Chile

C. Pardo Roa, M. Nelson, N. Ariyama, C. Aguayo, L. Almonacid, G. Munoz, C. Navarro, C. Avila, M. Ulloa, R. Reyes, E. Fuentes Luppichini, C. Mathieu, R. Vergara, A. Gonzalez, C. G. Gonzalez, , V. Neira-Ramirez

The paper tracks the emergence and mammalian adaptation of H5N1 HPAIV in Chile, identifying key mutations in the PB2 gene associated with cross-species transmission.

bioRxiv · Jun 30, 2023 · PreprintMicrobiology

Thermodynamic and kinetic analysis of the LAO binding protein and its isolated domains reveal non-additivity in stability, folding, and function

R. Vergara, T. Berrocal, E. I. Juarez Mejia, S. Romero-Romero, I. Velaquez-Lopez, N. Pulido, H. A. Lopez Sanchez, D.-A. Silva, M. Costas, A. Rodriguez-Romero, R. Rodriguez-Sotres, A. Sosa-Peinado, D. A. Fernandez-Velasco

This study analyzes the thermodynamic and kinetic properties of LAO and its domains, revealing non-additive effects in stability, folding, and function.

The FEBS Journal · May 29, 2023Peer-reviewedBiochemistry

De novo design of ACE2 protein decoys to neutralize SARS-CoV-2

T. W. Linsky, R. Vergara, N. Codina, J. W. Nelson, M. J. Walker, W. Su, T.-Y. Hsiang, K. Esser-Nobis, K. Yu, Y. J. Hou, T. Priya, M. Mitsumoto, A. Pong, U. Y. Lau, M. L. Mason, , D.-A. Silva

The paper designs de novo ACE2 protein decoys to neutralize SARS-CoV-2 by blocking viral entry, showing high affinity and potent in vitro inhibition.

bioRxiv · Aug 3, 2020Biochemistry

Mass cytometry analysis of the NK cell receptor-ligand repertoire reveals unique differences between dengue-infected children and adults

J. L. McKechnie, D. Beltran, A.-M. M. Ferreira, R. Vergara, L. Saenz, O. Vergara, D. Estripeaut, A. B. Arauz, L. J. Simpson, S. Holmes, S. Lopez-Verges, C. A. Blish

This study uses mass cytometry to compare NK cell receptor-ligand profiles between dengue-infected children and adults, identifying distinct immune signatures associated with infection outcomes.

bioRxiv · Jul 27, 2020Immunology

Charge-Altering Releasable Transporters enable specific phenotypic manipulation of resting primary natural killer cells

A. J. Wilk, N. L. Benner, R. Vergara, O. A. W. Haabeth, R. Levy, R. M. Waymouth, P. A. Wender, C. A. Blish

This study introduces CARTs, a non-viral transfection method for primary human NK cells, enabling efficient mRNA delivery without activation, preserving phenotype and function, and demonstrating therapeutic potential.

bioRxiv · Feb 28, 2020Immunology

TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells

E. Vendrame, C. Seiler, T. Ranganath, N. Q. Zhao, R. Vergara, M. Alary, A. C. Labbe, F. Guedou, J. Poudrier, S. Holmes, M. Roger, C. A. Blish

This study shows that TIGIT is upregulated on NK cells in untreated HIV+ individuals and marks a functional, mature NK cell subset with enhanced responses to HIV-infected targets.

bioRxiv · Sep 10, 2019Immunology

HLA upregulation during dengue virus infection suppresses the natural killer cell response

J. L. McKechnie, D. Beltran, A. Pitti, L. Saenz, A. B. Arauz, R. Vergara, E. Harris, L. L. Lanier, C. A. Blish, S. Lopez-Verges

This study shows that HLA class I upregulation during dengue virus infection suppresses natural killer cell activity, potentially contributing to disease progression.

bioRxiv · Jul 11, 2019Immunology