Author

A. J. Wilk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 5 Research Focus:cell-cell communication· 4 Research Focus:differential expression· 4 Approach:deep learning· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

C. A. Blish· 7 shared A. J. Rogers· 2 shared A. K. Shalek· 2 shared M. J. Lee· 2 shared N. Q. Zhao· 2 shared S. Holmes· 2 shared S. P. Holmes· 2 shared T. Ranganath· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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7 shared papersImmunology

C. A. Blish

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Author profile →

7 papers

Recent·Most cited

NK cell-monocyte crosstalk underlies NK cell activation in severe COVID-19

M. J. Lee, I. de los Rios Kobara, T. R. Barnard, X. Vales Torres, N. H. Tobin, K. G. Ferbas, A. W. J. Rimoin, O. O. Yang, G. M. Aldrovandi, A. J. Wilk, J. Fulcher, C. A. Blish

This study identifies NK cell-monocyte interactions as a driver of NK cell activation and dysfunction in severe COVID-19 through computational and in vitro experiments.

bioRxiv · Oct 27, 2023 · PreprintImmunology

Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality.

S. Dzanibe, A. J. Wilk, S. Canny, T. Ranganath, B. Alinde, F. Rubelt, H. Huang, M. Davis, S. P. Holmes, H. B. Jaspan, C. A. Blish, C. M. Gray

This study shows that HIV/ARV-exposed uninfected infants have reduced T cell receptor diversity and altered immune development, increasing infection risk.

bioRxiv · May 19, 2023 · PreprintImmunology

Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection

A. J. Wilk, J. O. Marceau, S. W. Kazer, I. Fleming, V. N. Miao, J. Galvez-Reyes, A. K. Shalek, S. Holmes, J. Overbaugh, C. A. Blish

This study identifies pro-inflammatory feedback loops in immune responses to pathogenic lentivirus infection, showing that highly pathogenic variants induce delayed, sustained, and amplifying inflammatory circuits.

bioRxiv · Mar 19, 2023Immunology

Comparative analysis of cell-cell communication at single-cell resolution

A. J. Wilk, A. K. Shalek, S. P. Holmes, C. A. Blish

This paper introduces Scriabin, a framework for analyzing cell-cell communication at single-cell resolution, validating its findings through multiple experimental approaches and demonstrating its application in uncovering communication pathways in health and disease.

bioRxiv · Feb 4, 2022Cell Biology

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

A. J. Wilk, M. J. Lee, B. Wei, B. Parks, R. Pi, G. J. Martinez-Colon, T. Ranganath, N. Q. Zhao, S. Taylor, W. Becker, Stanford COVID-19 Biobank, D. Jimenez-Morales, A. L. Blomkalns, R. O'Hara, E. A. Ashley, , C. A. Blish

Single-cell multi-omic profiling identifies immune dysregulation in severe COVID-19, including neutrophil hyperactivation and anti-inflammatory monocytes.

bioRxiv · Dec 18, 2020Immunology

Additional analyses exploring the hypothesized transdifferentiation of plasmablasts to developing neutrophils in severe COVID-19

A. J. Wilk, A. Rustagi, N. Q. Zhao, B. A. Martin, A. J. Rogers, C. A. Blish

The paper responds to criticisms of a previous study on transdifferentiation of plasmablasts to neutrophils in severe COVID-19 using single-cell transcriptomic data.

bioRxiv · Oct 15, 2020 · PreprintImmunology

Charge-Altering Releasable Transporters enable specific phenotypic manipulation of resting primary natural killer cells

A. J. Wilk, N. L. Benner, R. Vergara, O. A. W. Haabeth, R. Levy, R. M. Waymouth, P. A. Wender, C. A. Blish

This study introduces CARTs, a non-viral transfection method for primary human NK cells, enabling efficient mRNA delivery without activation, preserving phenotype and function, and demonstrating therapeutic potential.

bioRxiv · Feb 28, 2020Immunology