Author

W. Oosterheert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 3 Research Focus:protein structure prediction· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Belyy· 2 shared P. Gros· 2 shared S. Raunser· 2 shared A. Roy· 1 shared B. U. Klink· 1 shared F. Blanc· 1 shared G. Hummer· 1 shared J. Manshande· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

A. Belyy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments

W. Oosterheert, F. Blanc, A. Roy, A. Belyy, O. Hofnagel, G. Hummer, P. Bieling, S. Raunser

This study identifies a molecular backdoor mechanism for inorganic phosphate release from actin filaments, showing how a disease-linked mutation alters Pi release rates and filament structure.

bioRxiv · Mar 25, 2023Biochemistry

Structural basis of actin filament assembly and aging

W. Oosterheert, B. U. Klink, A. Belyy, S. Pospich, S. Raunser

This study presents cryo-EM structures of F-actin in all nucleotide states, revealing how water molecules drive ATP hydrolysis and filament dynamics, and explains differences in polymerization rates between Ca2+ and Mg2+-actin.

bioRxiv · Mar 29, 2022Biochemistry

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

W. Oosterheert, K. T. Xenaki, V. Neviani, W. Pos, S. Doulkeridou, J. Manshande, N. M. Pearce, L. M. J. Kroon-Batenburg, M. Lutz, P. M. P. van Bergen en Henegouwen, P. Gros

The paper presents crystal and cryo-EM structures of CD9 with nanobodies and EWI-F, revealing a tetrameric arrangement that provides a model for tetraspanin-enriched microdomain assembly.

Life Science Alliance · Nov 1, 2020Peer-reviewedBiophysics

Structural basis for targeting human cancer antigen STEAP1 with antibodies

W. Oosterheert, P. Gros

The paper presents a cryo-EM structure of STEAP1 bound to antibodies and shows it functions as a ferric reductase in hetero-trimers, providing insights for cancer therapy.

Journal of Biological Chemistry · Jul 1, 2020Peer-reviewedBiophysics