CGRP-receptor family reveals endogenous GPCR agonist bias and its significance in primary human cardiovascular cells
A. Clark, N. Mullooly, D. Safitri, M. Harris, T. de Vries, A. M. Van Den Brink, D. R. Poyner, D. Gianni, M. Wigglesworth, G. Ladds
The paper demonstrates endogenous agonist bias at the calcitonin-like receptor in primary human cardiovascular cells, showing physiological consequences through RAMP switching.
bioRxiv · Dec 21, 2020 · PreprintPharmacology & Toxicology