Author

D. R. Poyner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Safitri· 2 shared G. Ladds· 2 shared M. Harris· 2 shared A. Clark· 1 shared A. Inoue· 1 shared A. M. Van Den Brink· 1 shared B. Al-Zaid· 1 shared B. Hoare· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

D. Safitri

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Author profile →

3 papers

Recent·Most cited

RAMPs regulate signalling bias and internalisation of the GIPR

M. Harris, D. I. Mackie, J. B. Pawlak, S. Carvalho, T. T. truong, D. Safitri, H. Y. Yeung, S. Routledge, M. T. Harper, B. Al-Zaid, M. Soave, S. Al-Sabah, A. Inoue, D. R. Poyner, S. J. Hill, , G. Ladds

This study shows RAMPs modulate GIPR signaling and internalization, with RAMP3 reducing cAMP production and promoting surface retention, while RAMP1/2 decrease Gq/11/15 activation, and RAMP1 is essential for normal glucose regulation.

bioRxiv · Apr 8, 2021 · PreprintPharmacology & Toxicology

CGRP-receptor family reveals endogenous GPCR agonist bias and its significance in primary human cardiovascular cells

A. Clark, N. Mullooly, D. Safitri, M. Harris, T. de Vries, A. M. Van Den Brink, D. R. Poyner, D. Gianni, M. Wigglesworth, G. Ladds

The paper demonstrates endogenous agonist bias at the calcitonin-like receptor in primary human cardiovascular cells, showing physiological consequences through RAMP switching.

bioRxiv · Dec 21, 2020 · PreprintPharmacology & Toxicology

Functional solubilisation of the β2-adrenoceptor (β2AR) using Diisobutylene maleic acid (DIBMA).

C. R. Harwood, D. A. Sykes, B. Hoare, F. M. Heydenreich, R. Uddin, D. R. Poyner, S. J. Briddon, D. B. Veprintsev

This paper demonstrates the functional solubilisation of the β2-adrenoceptor using DIBMA, showing improved thermal stability compared to detergent-based methods.

bioRxiv · Jun 29, 2020Biochemistry