Integrative solution structure of a PTBP1-viral IRES complex reveals strong compaction and ordering with residual conformational flexibility
G. Dorn, C. Gmeiner, T. de Vries, E. Dedic, M. Novakovic, F. F. Damberger, C. Maris, E. Finol, C. P. Sarnowski, J. Kolhbrecher, T. J. Welsh, S. Bolisetty, R. Mezzenga, R. Aebersold, A. Leitner, , F. H.- T. Allain
The paper determines the solution structure of a PTBP1-viral IRES complex using integrative modeling, revealing compaction, ordering, and residual flexibility essential for IRES-mediated translation.
bioRxiv · Jul 8, 2022Biochemistry