Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians
Z. Deng, J. Zhen, G. F. Harrison, G. Zhang, R. Chen, G. Sun, Q. Yu, N. Nemat-Gorgani, L. A. Guethlein, L. He, M. Tang, X. Gao, S. Cai, J. A. Shortt, C. R. Gignoux, , P. J. Norman
The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.
bioRxiv · Jul 29, 2020Immunology