Author

G. F. Harrison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. R. Gignoux· 2 shared P. J. Norman· 2 shared A. Dumaine· 1 shared B. A. Lie· 1 shared C. M. Bergey· 1 shared D. Vukcevic· 1 shared E. A. Harrison· 1 shared E. Schurr· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

C. R. Gignoux

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Allele imputation for the Killer cell Immunoglobulin-like Receptor KIR3DL1/S1

G. F. Harrison, L. A. Leaton, E. A. Harrison, M. K. Viken, J. Shortt, C. R. Gignoux, B. A. Lie, D. Vukcevic, S. Leslie, P. J. Norman

This paper develops PONG, a method to impute KIR3DL1/S1 alleles from whole-genome SNP data with high accuracy across populations, enabling large-scale genetic studies.

PLOS Computational Biology · Feb 22, 2022Peer-reviewedImmunology

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

Z. Deng, J. Zhen, G. F. Harrison, G. Zhang, R. Chen, G. Sun, Q. Yu, N. Nemat-Gorgani, L. A. Guethlein, L. He, M. Tang, X. Gao, S. Cai, J. A. Shortt, C. R. Gignoux, , P. J. Norman

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

bioRxiv · Jul 29, 2020Immunology

Natural selection contributed to immunological differences between human hunter-gatherers and agriculturalists

G. F. Harrison, J. Sanz, J. Boulais, M. J. Mina, J.-C. Grenier, Y. Leng, A. Dumaine, V. Yotova, C. M. Bergey, S. J. Elledge, E. Schurr, L. Quintana-Murci, G. H. Perry, L. B. Barreiro

The paper compares transcriptional immune responses between hunter-gatherers and agriculturalists, finding greater divergence in viral response and evidence of natural selection in hunter-gatherers.

bioRxiv · Dec 4, 2018Evolutionary Biology