Author

P. J. Norman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. R. Gignoux· 2 shared G. F. Harrison· 2 shared L. A. Leaton· 2 shared L. Loh· 2 shared M. Stone· 2 shared A. Campos Codo· 1 shared A. Getahun· 1 shared A. Spengler· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

C. R. Gignoux

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Author profile →

5 papers

Recent·Most cited

Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse Models

L. Loh, S. Carcy, H. S. Krovi, J. Domenico, A. Spengler, Y. Lin, J. D. Torres, W. Palmer, P. J. Norman, M. Stone, T. Brunetti, H. V. Meyer, L. Gapin

This study compares human innate-like T cells (Tinn) with conventional T cells and mouse models, revealing distinct transcriptional programs and developmental pathways.

bioRxiv · Dec 7, 2023Immunology

Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells.

W. H. Palmer, L. A. Leaton, A. Campos Codo, P. S. Hume, B. Crute, M. Stone, A. van Bokhoven, R. P. Tobin, M. McCarter, W. J. Janssen, J. Roest, S. Zhu, J. Petersen, J. P. Vivian, J. Rossjohn, , P. J. Norman

This study identifies KIR3DL3 expression in T cells, showing it is upregulated by unconventional stimulation and varies by individual genetic variants.

bioRxiv · Aug 17, 2022Immunology

Allele imputation for the Killer cell Immunoglobulin-like Receptor KIR3DL1/S1

G. F. Harrison, L. A. Leaton, E. A. Harrison, M. K. Viken, J. Shortt, C. R. Gignoux, B. A. Lie, D. Vukcevic, S. Leslie, P. J. Norman

This paper develops PONG, a method to impute KIR3DL1/S1 alleles from whole-genome SNP data with high accuracy across populations, enabling large-scale genetic studies.

PLOS Computational Biology · Feb 22, 2022Peer-reviewedImmunology

High-throughput Interpretation of Killer-cell Immunoglobulin-like Receptor Short-read Sequencing Data with PING

W. Marin, R. Dandekar, D. G. Augusto, T. Yusufali, B. Heyn, J. Hofmann, V. Lange, J. Sauter, P. J. Norman, J. A. Hollenbach

PING enables high-throughput, accurate KIR genotyping by addressing structural complexity and homology challenges in short-read sequencing data.

bioRxiv · Mar 24, 2021Immunology

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

Z. Deng, J. Zhen, G. F. Harrison, G. Zhang, R. Chen, G. Sun, Q. Yu, N. Nemat-Gorgani, L. A. Guethlein, L. He, M. Tang, X. Gao, S. Cai, J. A. Shortt, C. R. Gignoux, , P. J. Norman

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

bioRxiv · Jul 29, 2020Immunology