Author

C. R. Gignoux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

G. F. Harrison· 2 shared P. J. Norman· 2 shared B. A. Lie· 1 shared D. Vukcevic· 1 shared E. A. Harrison· 1 shared G. Sun· 1 shared G. Zhang· 1 shared H. Zou· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

G. F. Harrison

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2 papers

Recent·Most cited

Allele imputation for the Killer cell Immunoglobulin-like Receptor KIR3DL1/S1

G. F. Harrison, L. A. Leaton, E. A. Harrison, M. K. Viken, J. Shortt, C. R. Gignoux, B. A. Lie, D. Vukcevic, S. Leslie, P. J. Norman

This paper develops PONG, a method to impute KIR3DL1/S1 alleles from whole-genome SNP data with high accuracy across populations, enabling large-scale genetic studies.

PLOS Computational Biology · Feb 22, 2022Peer-reviewedImmunology

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

Z. Deng, J. Zhen, G. F. Harrison, G. Zhang, R. Chen, G. Sun, Q. Yu, N. Nemat-Gorgani, L. A. Guethlein, L. He, M. Tang, X. Gao, S. Cai, J. A. Shortt, C. R. Gignoux, , P. J. Norman

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

bioRxiv · Jul 29, 2020Immunology