Author

N. Pirot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

A. B. Aznar· 2 shared D. Fisher· 2 shared F. Bernex· 2 shared G. Dubra· 2 shared L. Krasinska· 2 shared S. Prieto· 2 shared A. Camasses· 1 shared A. Castet-Nicolas· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

A. B. Aznar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

RIP140 regulates HES1 oscillatory expression and mitogenic activity in colon cancer cells

N. Sfeir, M. Kajdan, S. Jalaguier, S. Bonnet, C. Teyssier, S. Pyrdziak, R. Yuan, E. Bousquet, A. Maraver, F. Bernex, N. Pirot, F. Boissiere, A. Castet-Nicolas, M. Lapierre, V. Cavailles

This study shows RIP140 regulates HES1 expression and mitogenic activity in colon cancer cells, with implications for patient survival.

bioRxiv · May 13, 2023 · PreprintCancer Biology

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

S. Prieto, G. Dubra, A. Camasses, E. Simboeck, A. B. Aznar, C. Begon-Pescia, N. Pirot, F. Gerbe, L. Angevin, P. Jay, L. Krasinska, D. Fisher

The paper shows CDK8 and CDK19 redundantly regulate the CFTR pathway in intestinal epithelium, leading to mucus accumulation and goblet cell secretion when both are deleted.

bioRxiv · Jan 28, 2022Cell Biology

In Lyl1-/- mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues

A. Hussain, L. El Kebriti, V. Deleuze, Y. Glasson, N. Pirot, D. Mathieu, V. PINET

This study shows that Lyl1 deficiency in mice causes vascular niche impairment in adipose tissue, leading to premature adipocyte differentiation and fat tissue expansion.

bioRxiv · Apr 24, 2020Physiology

Ki-67 promotes sequential stages of tumourigenesis by enabling cellular plasticity

K. Mrouj, P. Singh, M. Sobecki, G. Dubra, E. Al Ghoul, A. B. Aznar, S. prieto, N. Pirot, F. Bernex, B. Bordignon, C. Hassen-Khodja, M. Pouzolles, V. Zimmerman, V. Dardalhon, L. Krasinska, D. Fisher

This study shows Ki-67 enables cellular plasticity across tumourigenesis stages, with knockout inhibiting tumour growth and metastasis through transcriptome remodelling and angiogenesis disruption.

bioRxiv · Dec 13, 2019Cancer Biology

The mouse HP1 proteins are essential for preventing liver tumorigenesis

N. Saksouk, S. Hajdari, M. Pratlong, C. Barrachina, C. Graber, A. Zavoriti, A. Sarrazin, N. Pirot, J.-Y. Noël, L. Khellaf, E. Fabbrizio, E. Julien, F. M. Cammas

This study shows that HP1 proteins prevent liver tumors in mice by maintaining chromatin structure and gene expression, and by suppressing retroviral activity.

bioRxiv · Apr 1, 2019Cancer Biology