Author

V. Dardalhon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2

Frequent Co-Authors

N. Taylor· 3 shared M. I. Matias· 2 shared S. Kinet· 2 shared V. S. Zimmermann· 2 shared A. B. Aznar· 1 shared A. Foroushani· 1 shared A. H. Abid· 1 shared A. Joly· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

N. Taylor

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single molecule DNA methylation and hydroxymethylation reveal unique epigenetic identity profiles of T helper cells

C. Goldsmith, O. Fesneau, V. Thevin, M. I. Matias, J. Perrault, A. H. Abid, N. Taylor, V. Dardalhon, J. C. Marie, H. Hernandez-Vargas

The paper develops a method to profile DNA methylation and hydroxymethylation in T helper cells, revealing their role in cell identity and potential for studying autoimmune disease mechanisms.

bioRxiv · Feb 3, 2023 · PreprintImmunology

Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives erythroid lineage differentiation

P. Gonzalez-Menendez, I. Phadke, M. E. Olive, K. L. McGraw, J. Platon, J. Papoin, H. Yan, M. Daumur, F. Paul, R. Mirmira, A. Joly, J. Galtier, A. Narla, G. Cartron, V. Dardalhon, , N. Taylor

The paper shows that arginine metabolism via hypusination of eIF5A regulates erythroid differentiation and that impaired eIF5A activity leads to erythroid disorders.

bioRxiv · Mar 21, 2022 · PreprintPhysiology

Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of primary and metastatic hepatocellular carcinoma

A. Lozano, F.-R. Souche, C. Ramirez, S. Vegna, G. Desandre, A. Riviere, V. Dardalhon, A. Zine El Aabidine, P. Fort, L. Akkari, U. Hibner, D. Gregoire

This study shows that varying levels of MAPK Erk signaling in Ras-transformed cells influence tumor growth and immune evasion in a mouse model of hepatocellular carcinoma.

bioRxiv · Aug 13, 2021Cancer Biology

Alpha-ketoglutarate inhibits Regulatory T cell differentiation by coupling lipidome remodelling to mitochondrial metabolism

M. I. Matias, C. S. Yong, A. Foroushani, E. Sezgin, K. R. Levental, A. Talebi, C. Mongellaz, J. Dehair, M. Wong, S. Kinet, V. S. Zimmermann, I. Levental, L. Yvan-Charvet, J. v. Swinnen, S. Muljo, , N. Taylor

This study shows that alpha-ketoglutarate inhibits regulatory T cell differentiation by altering lipid metabolism and mitochondrial function.

bioRxiv · Aug 24, 2020 · PreprintImmunology

Ki-67 promotes sequential stages of tumourigenesis by enabling cellular plasticity

K. Mrouj, P. Singh, M. Sobecki, G. Dubra, E. Al Ghoul, A. B. Aznar, S. prieto, N. Pirot, F. Bernex, B. Bordignon, C. Hassen-Khodja, M. Pouzolles, V. Zimmerman, V. Dardalhon, L. Krasinska, D. Fisher

This study shows Ki-67 enables cellular plasticity across tumourigenesis stages, with knockout inhibiting tumour growth and metastasis through transcriptome remodelling and angiogenesis disruption.

bioRxiv · Dec 13, 2019Cancer Biology