Author

N. R. Mantuano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

C. R. Bertozzi· 2 shared A. Kuo· 1 shared A. Petrone· 1 shared A. S. Kashyap· 1 shared A. Zippelius· 1 shared B. Kasenda· 1 shared B. M. George· 1 shared C. L. Miller· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

C. R. Bertozzi

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2 papers

Recent·Most cited

ImmunologyScience Translational MedicinePeer-reviewedNov 2, 2022

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

M. A. Stanczak, N. R. Mantuano, N. Kirchhammer…·H. Laeubli

This study shows that targeting cancer glycosylation with an antibody-sialidase conjugate repolarizes tumor-associated macrophages and enhances immune checkpoint blockade efficacy in mouse models.

DOI 10.1126/scitranslmed.abj1270

mousebulk RNA-seq

𝕏 PostBluesky

BiochemistrybioRxivMay 20, 2022

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

K. Pedram, D. J. Shon, G. S. Tender…·C. R. Bertozzi

This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.

DOI 10.1038/s41587-023-01840-6

mouseproteomics

𝕏 PostBluesky