Author

N. Kirchhammer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Zippelius· 3 shared M. A. Stanczak· 3 shared G. Monaco· 2 shared H. Laubli· 2 shared M. P. Trefny· 2 shared A. Carlos Fonseca· 1 shared A. Filardy· 1 shared A. Kashyap· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

A. Zippelius

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells

N. Kirchhammer, M. P. Trefny, M. Natoli, D. Bruecher, S. N. Smith, F. Werner, V. Koch, D. Schreiner, E. Bartoszek, M. Buchi, M. Schmid, D. Breu, K. P. Hartmann, P. Zaytseva, D. S. Thommen, , A. Zippelius

The paper shows that CCL5-producing tissue-resident NK cells are critical for IL-12-mediated anti-tumor immunity and that CCL5 delivery can overcome resistance in tumors with low trNK cell infiltration.

bioRxiv · May 27, 2021 · PreprintImmunology

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

M. A. Stanczak, N. R. Mantuano, N. Kirchhammer, D. E. Sanin, J. Wang, M. P. Trefny, G. Monaco, M. A. Gray, A. Petrone, A. S. Kashyap, K. Glatz, B. Kasenda, K. Normington, J. Broderick, L. Peng, , H. Laeubli

This study shows that targeting cancer glycosylation with an antibody-sialidase conjugate repolarizes tumor-associated macrophages and enhances immune checkpoint blockade efficacy in mouse models.

bioRxiv · Apr 11, 2021Immunology

Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation

N. Rodrigues Mantuano, M. A. Stanczak, I. de Araujo Oliveira, N. Kirchhammer, A. Filardy, G. Monaco, R. C. Santos, A. Carlos Fonseca, M. Fontes, C. de Souza Bastos, W. B. Dias, A. Zippelius, A. R. Todeschini, H. Laubli

This study shows hyperglycemia promotes cancer immune evasion by increasing O-GlcNAcylation in tumor-associated macrophages, shifting their polarization to a pro-tumorigenic M2-like phenotype.

bioRxiv · Nov 5, 2019Cancer Biology