Author

N. R. Salama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:imaging· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

V. P. O'Brien· 3 shared C. Leverich· 2 shared L. K. Jackson· 2 shared A. E. R. Martinez· 1 shared A. E. Rodriguez Martinez· 1 shared B. P. Bratton· 1 shared B. Potter· 1 shared B. Wei· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersMicrobiology

V. P. O'Brien

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-specific inflammation

V. P. O'Brien, Y. Kang, M. K. Shenoy, G. Finak, W. C. Young, J. Dubrulle, L. Koch, A. E. R. Martinez, J. A. Snow, J. Williams, E. Donato, S. K. Batra, C. C. Yeung, S. Bullman, M. A. Koch, , N. R. Salama

The paper identifies a Muc4-expressing metaplastic gastric cell type in mice driven by H. pylori inflammation and shows its association with proliferation in human gastric cancer.

bioRxiv · Dec 20, 2022 · PreprintMicrobiology

Helicobacter pylori chronic infection selects for effective colonizers of metaplastic glands

V. P. O'Brien, L. K. Jackson, J. Frick, A. E. Rodriguez Martinez, D. S. Jones, C. D. Johnston, N. R. Salama

The paper shows that H. pylori strains from later stages of infection are better at colonizing metaplastic gastric tissue, linked to genetic variation in the sabB gene.

bioRxiv · Jun 13, 2022Microbiology

Helicobacter pylori diversification during chronic infection within a single host generates sub-populations with distinct phenotypes

L. K. Jackson, B. Potter, S. E. Schneider, M. Fitzgibbon, K. Blair, H. Farah, U. Krishna, R. Peek, T. Bedford, N. R. Salama

This study tracks genetic and phenotypic changes in Helicobacter pylori isolates from a single host over six years, revealing sub-populations with distinct genetic and functional traits.

bioRxiv · Jun 10, 2020Microbiology

Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

J. A. Taylor, B. P. Bratton, S. R. Sichel, K. M. Blair, H. M. Jacobs, K. E. DeMeester, E. Kuru, J. Gray, J. Biboy, M. S. VanNieuwenhze, W. Vollmer, C. L. Grimes, J. W. Shaevitz, N. R. Salama

The paper identifies cytoskeletal proteins that regulate cell wall synthesis in Helicobacter pylori, linking their distribution to specific Gaussian curvatures that maintain helical shape.

bioRxiv · Feb 10, 2019Microbiology

Non-helical Helicobacter pylori show altered gland colonization and elicit less gastric pathology during chronic infection

L. E. Martinez, V. P. O'Brien, C. Leverich, S. E. Knoblaugh, N. R. Salama

This study compares the colonization and pathogenicity of helical and straight rod Helicobacter pylori strains in mice, finding that straight rods show reduced inflammation during chronic infection.

bioRxiv · Dec 26, 2018Microbiology

Increased H. pylori stool shedding and EPIYA-D cagA alleles are associated with gastric cancer in an East Asian hospital

S. Talarico, C. Leverich, B. Wei, J. Ma, X. Cao, Y. Guo, G. Han, L. Yao, S. Self, Y. Zhao, N. R. Salama

The paper assesses H. pylori stool shedding and cagA genotype in gastric cancer patients and non-cancer controls, finding higher stool shedding and association with the East Asian cagA allele.

bioRxiv · Mar 20, 2018Microbiology