Author

J. Dubrulle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 3 Biophysics· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell signaling & trafficking· 6 Research Focus:cell type annotation· 4 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metagenomics· 2

Frequent Co-Authors

E. C. Holmes· 2 shared J. L. Geoghegan· 2 shared J. R. Wierenga· 2 shared V. P. O'Brien· 2 shared A. E. Brent· 1 shared A. E. R. Martinez· 1 shared A. I. Yashchenko· 1 shared A. Koehne· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersMicrobiology

E. C. Holmes

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Author profile →

10 papers

Recent·Most cited

Viromes of Antarctic fish resembles the diversity found at lower latitudes

R. M. Grimwood, S. J. Waller, J. R. Wierenga, L. Lim, J. Dubrulle, E. C. Holmes, J. L. Geoghegan

The paper analyzes viromes of Antarctic fish to compare viral diversity with lower latitude fish, finding comparable complexity and evidence of host-switching and viral adaptation.

bioRxiv · Apr 29, 2024Microbiology

Atg8-LC3 controls systemic nutrient surplus signaling from flies to humans.

A. Madan, K. P. Kelly, C. E. Sullivan, M. E. Poling, A. E. Brent, M. Alassaf, J. Dubrulle, A. Rajan

This study identifies Atg8-LC3's role in leptin secretion across species, linking autophagy proteins to nutrient surplus signaling and organismal resilience.

bioRxiv · May 31, 2023 · PreprintPhysiology

A high-content screen reveals new regulators of nuclear membrane stability

A. L. Gunn, A. I. Yashchenko, J. Dubrulle, J. Johnson, E. L. Hatch

This study identifies new regulators of nuclear membrane stability through a high-content siRNA screen and automated image analysis in cancer cells.

bioRxiv · May 30, 2023Cell Biology

Direct observation of coordinated assembly of individual native centromeric nucleosomes

A. Popchock, J. Larson, J. Dubrulle, C. L. Asbury, S. Biggins

The paper develops a microscopy assay to study centromeric nucleosome assembly, showing CENP-A can reach centromeres without HJURP but requires it for stable incorporation and AT-rich DNA for efficient deposition.

bioRxiv · Jan 20, 2023Biophysics

Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-specific inflammation

V. P. O'Brien, Y. Kang, M. K. Shenoy, G. Finak, W. C. Young, J. Dubrulle, L. Koch, A. E. R. Martinez, J. A. Snow, J. Williams, E. Donato, S. K. Batra, C. C. Yeung, S. Bullman, M. A. Koch, , N. R. Salama

The paper identifies a Muc4-expressing metaplastic gastric cell type in mice driven by H. pylori inflammation and shows its association with proliferation in human gastric cancer.

bioRxiv · Dec 20, 2022 · PreprintMicrobiology

Cas phosphorylation regulates focal adhesion assembly

S. Kumar, A. Stainer, J. Dubrulle, C. Simpkins, J. Cooper

The paper shows that Cas phosphorylation and clustering with Crk/CrkL and inactive integrin β1 precede focal adhesion assembly, with Rac1 and ubiquitin proteasome system regulating this process.

bioRxiv · Dec 19, 2022Cell Biology

A novel gyrovirus associated with a fatal respiratory disease in yellow-eyed penguin (Megadyptes antipodes) chicks

J. R. Wierenga, K. J. Morgan, S. Hunter, H. S. Taylor, L. S. Argilla, T. Webster, J. Dubrulle, F. Jorge, M. Bostina, L. Burga, E. C. Holmes, K. McInnes, J. L. Geoghegan

The paper identifies a novel gyrovirus associated with respiratory distress syndrome in yellow-eyed penguin chicks through metatranscriptomic analysis of tissue samples.

bioRxiv · Sep 15, 2022 · PreprintMicrobiology

Cell wound repair requires the coordinated action of linear and branched actin nucleation factors

J. Hui, M. Nakamura, J. Dubrulle, S. M. Parkhurst

This study shows that branched actin nucleators scaffold the contractile actomyosin cable during wound repair, and their removal leads to alternative mechanisms of wound closure through linear actin filaments.

bioRxiv · Apr 14, 2022Cell Biology

Helicobacter pylori accelerates KRAS-dependent gastric dysplasia

V. P. O'Brien, A. Koehne, J. Dubrulle, A. Rodriguez, C. Leverich, P. Kong, J. Campbell, R. Pierce, J. Goldenring, E. Choi, N. Salama

This study shows that Helicobacter pylori infection accelerates KRAS-driven gastric dysplasia in mice by promoting inflammation, altering gene expression, and increasing proliferation of preneoplastic glands.

bioRxiv · Oct 6, 2020Cancer Biology

Chronic starvation induces non-canonical pro-death stress granules

L. C. Reineke, S. A. Cheema, J. Dubrulle, J. R. Neilson

This study identifies a novel type of stress granule formed during chronic starvation that promotes cell death, differing from classical stress granules associated with survival.

bioRxiv · May 9, 2018Cell Biology