N. S. Singhal

Suppressing APOE4-induced mortality and cellular damage by targeting VHL

This study shows that targeting the VHL-HIF axis suppresses mortality and cellular damage caused by APOE4 and other stressors in C. elegans and mice.

Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrels

This study identifies a naturally occurring ATP5G1 variant in Arctic ground squirrels that enhances mitochondrial function and cell resilience to metabolic stress through a specific amino acid substitution.