B. Y. Winer

Suppressing APOE4-induced mortality and cellular damage by targeting VHL

This study shows that targeting the VHL-HIF axis suppresses mortality and cellular damage caused by APOE4 and other stressors in C. elegans and mice.

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.

Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells

This study shows that plasma membrane abundance regulates phagocytic capacity and post-phagocytic migration in myeloid cells, with G{beta}4 deficiency leading to increased phagocytosis and altered trafficking.

Persistent hepatitis B virus and HIV coinfections in dually humanized mice engrafted with human liver and immune system

This study shows that dually humanized mice can support persistent HBV and HIV coinfections, enabling research on immune dysregulation and immunotherapeutic testing.

Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis

The paper analyzes immune cell interactions using traction force microscopy to identify biomechanical features associated with cytotoxic T cell activity.

Apoptotic contraction drives target cell release by cytotoxic T cells

This study identifies apoptotic contraction as a mechanism driving CTL dissociation and target cell release.

A Kinesin-3 Recruitment Complex Facilitates Axonal Sorting of Enveloped Alpha Herpesvirus Capsids

This study identifies a viral complex that recruits kinesin-3 motors to facilitate axonal sorting of herpesvirus capsids.