Author

V. S. De Paula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Dubey· 1 shared C. R. Glassman· 1 shared H. Arthanari· 1 shared K. C. Garcia· 1 shared K. M. Jude· 1 shared N. G. Sgourakis· 1 shared N. Sgourakis· 1 shared S. Nerli· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 13 mutual co-author links

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1 shared paperBiochemistry

A. Dubey

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2 papers

Recent·Most cited

A slow-exchange conformational switch regulates off-target cleavage by high-fidelity Cas9

V. S. De Paula, A. Dubey, H. Arthanari, N. Sgourakis

This study identifies a conformational switch in Cas9 that reduces off-target cleavage by enabling REC3 domain scanning for proper base pairing.

bioRxiv · Dec 6, 2020 · PreprintBiochemistry

Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch

V. S. De Paula, K. M. Jude, S. Nerli, C. R. Glassman, K. C. Garcia, N. G. Sgourakis

This study identifies a helical capping switch in IL-2 that modulates its conformational transitions and drug interactions, providing a framework for designing precision therapeutics.

bioRxiv · Oct 28, 2019Biochemistry