Antigen and Checkpoint Receptor Recalibration of T Cell Receptor Signal Strength
T. A. E. Elliot, E. K. Jennings, D. A. J. Lecky, N. Thawait, A. Flores-Langarica, D. C. Wraith, D. Bending
This study identifies how TCR signal strength modulates CD4+ T cell function and shows that anti-PD1 therapy increases TCR signal strength, defining a metric to stratify melanoma patient outcomes.
bioRxiv · Mar 2, 2021Immunology