Author

K.-M. Toellner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:cell signaling & trafficking· 1 Assay:flow cytometry· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. C. Yam-Puc· 3 shared L. Zhang· 3 shared Y. Zhang· 3 shared L. Garcia-Ibanez· 2 shared A. Alshayea· 1 shared A. Camara· 1 shared A. E. Hauser· 1 shared A. E. Schager· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersImmunology

J. C. Yam-Puc

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TIMBIM4 safeguards IgG1+ GC B cell positive selection

L. Zhang, A. Toboso-Navasa, A. Gunawan, A. Camara, R. Nakagawa, K. Finsterbusch, P. Chakravarty, R. Newman, Y. Zhang, M. Eilers, A. Wack, P. Tolar, K.-M. Toellner, D. P. Calado

This study identifies MIZ1-TMBIM4 as a mechanism safeguarding IgG1+ GC B cell positive selection by regulating Ca2+ mobilization and preventing mitochondrial dysfunction.

bioRxiv · Jul 18, 2023 · PreprintImmunology

Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses

S. E. Jossi, M. Arcuri, A. Alshayea, R. R. Persaud, E. Marcial-Juarez, E. Palmieri, R. Di Benedetto, M. Perez-Toledo, J. Pillaye, W. M. Channell, A. E. Schager, R. E. Lamerton, C. N. Cook, M. Goodall, T. Hanaeda, , A. F. Cunningham

This study compares the efficacy of Vi polysaccharide and conjugated Vi vaccines in protecting against Salmonella Typhi, finding that conjugated vaccines sustain immune responses better over time.

bioRxiv · Jan 3, 2023 · PreprintImmunology

Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism

H. A. Penny, R. G. Domingues, M. Z. Krauss, F. Melo-Gonzalez, S. Dickson, J. Parkinson, M. Hurry, C. Purse, E. Jegham, C. Godinho-Silva, M. Rendas, H. Veiga-Fernandes, D. Bechtold, R. K. Grencis, K.-M. Toellner, , M. R. Hepworth

This study shows diurnal rhythms in intestinal IgA regulate oscillations in commensal microbiota abundance, promoting mutualism.

bioRxiv · Oct 11, 2021Immunology

Memory-like B cells emerging from germinal centres recycle through the subcapsular sinus

Y. Zhang, L. Garcia-Ibanez, C. Ulbricht, L. S. C. Lok, T. W. Dennison, J. R. Ferdinand, J. Mueller-Winkler, C. J. M. Burnett, J. C. Yam-Puc, L. Zhang, G. Brown, V. Tybulewicz, A. Rot, A. E. Hauser, M. R. Clatworthy, K.-M. Toellner

The paper tracks B cells exiting germinal centers and shows they recycle through the subcapsular sinus, interacting with macrophages and returning to GCs via CCL21 gradients, supporting affinity maturation to antigenic drift.

bioRxiv · Dec 8, 2020 · PreprintImmunology

Enhanced BCR signalling inflicts early plasmablast and germinal centre B cell death

J. C. Yam-Puc, L. Zhang, R. A. Maqueda-Alfaro, L. Garcia-Ibanez, Y. Zhang, J. Davies, Y. A. Senis, M. Snaith, K.-M. Toellner

This study shows that enhanced BCR signaling leads to early plasmablast and GC B cell death, affecting affinity maturation and B cell tolerance.

bioRxiv · Jul 29, 2020Immunology

Differential Nr4a1 and Nr4a3 expression discriminates tonic from activated TCR signalling events in vivo

E. K. Jennings, T. A. E. Elliot, N. Thawait, S. S. Kanabar, J. C. Yam-Puc, M. Ono, K.-M. Toellner, D. C. Wraith, G. Anderson, D. Bending

The paper identifies differential Nr4a1 and Nr4a3 expression as markers distinguishing tonic from activating TCR signalling in T cells.

bioRxiv · Jan 15, 2020Immunology