Author

J. C. Yam-Puc

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:flow cytometry· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

K.-M. Toellner· 3 shared L. Garcia-Ibanez· 2 shared L. Zhang· 2 shared N. J. Matheson· 2 shared Y. Zhang· 2 shared A. Bermperi· 1 shared A. Correa-Noguera· 1 shared A. E. Hauser· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

K.-M. Toellner

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Author profile →

6 papers

Recent·Most cited

An evolutionary-conserved VPS34-PIKfyve-TRPML1-Myosin II axis regulates the speed of amoeboid cell migration

P. Dehio, C. Michard, J. C. Yam-Puc, A.-A. Marti i Lindez, L. Fabre, T. Schaefer, M. P. Wymann, K. Okkenhaug, T. Soldati, M. Mehling, C. Hess

This study identifies a conserved VPS34-PIKfyve-TRPML1-Myosin II axis that controls the speed of amoeboid cell migration by regulating retrograde actin flow through Ca2+ efflux.

bioRxiv · Jan 22, 2024Cell Biology

Gut microbiome remains stable following COVID-19 vaccination in healthy and immuno-compromised individuals

R. H. Boston, R. Guan, L. Kalmar, S. Beier, E. C. Horner, N. Beristain-Covarrubias, J. C. Yam-Puc, P. P. Gerber, L. Faria, A. Kuroshchenkova, A. E. Lindell, S. Blasche, A. Correa-Noguera, A. Elmer, C. Saunders, , K. R. Patil

This study shows that the gut microbiome remains stable after COVID-19 vaccination in both healthy and immuno-compromised individuals, with no significant changes in diversity, phylum, species, or functional capacity.

bioRxiv · Aug 23, 2023Microbiology

Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies

K. Fischer, A. Lulla, T. So, P. Pereyra-Gerber, M. I. J. Raybould, T. N. Kohler, T. S. Kaminski, J. C. Yam-Puc, R. Hughes, F. Leiss-Maier, P. Brear, N. J. Matheson, C. Deane, M. Hyvonen, J. Thaventhiran, F. Hollfelder

This paper presents a microfluidics-based method to rapidly discover monoclonal antibodies from antigen-specific antibody secreting cells, achieving high-affinity and neutralizing antibodies against SARS-CoV-2.

bioRxiv · Jan 10, 2023Immunology

Memory-like B cells emerging from germinal centres recycle through the subcapsular sinus

Y. Zhang, L. Garcia-Ibanez, C. Ulbricht, L. S. C. Lok, T. W. Dennison, J. R. Ferdinand, J. Mueller-Winkler, C. J. M. Burnett, J. C. Yam-Puc, L. Zhang, G. Brown, V. Tybulewicz, A. Rot, A. E. Hauser, M. R. Clatworthy, K.-M. Toellner

The paper tracks B cells exiting germinal centers and shows they recycle through the subcapsular sinus, interacting with macrophages and returning to GCs via CCL21 gradients, supporting affinity maturation to antigenic drift.

bioRxiv · Dec 8, 2020 · PreprintImmunology

Enhanced BCR signalling inflicts early plasmablast and germinal centre B cell death

J. C. Yam-Puc, L. Zhang, R. A. Maqueda-Alfaro, L. Garcia-Ibanez, Y. Zhang, J. Davies, Y. A. Senis, M. Snaith, K.-M. Toellner

This study shows that enhanced BCR signaling leads to early plasmablast and GC B cell death, affecting affinity maturation and B cell tolerance.

bioRxiv · Jul 29, 2020Immunology

Differential Nr4a1 and Nr4a3 expression discriminates tonic from activated TCR signalling events in vivo

E. K. Jennings, T. A. E. Elliot, N. Thawait, S. S. Kanabar, J. C. Yam-Puc, M. Ono, K.-M. Toellner, D. C. Wraith, G. Anderson, D. Bending

The paper identifies differential Nr4a1 and Nr4a3 expression as markers distinguishing tonic from activating TCR signalling in T cells.

bioRxiv · Jan 15, 2020Immunology