Author

N. Z. Lue

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

E. M. Garcia· 2 shared B. B. Liau· 1 shared B. Liau· 1 shared C. Lee· 1 shared D. D. Hwang· 1 shared J. G. Doench· 1 shared J. K. Liang· 1 shared J. Woods· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

E. M. Garcia

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Author profile →

2 papers

Recent·Most cited

Base Editor Scanning Reveals Activating Mutations of DNMT3A

E. M. Garcia, N. Z. Lue, J. K. Liang, W. K. Lieberman, D. D. Hwang, J. Woods, B. Liau

The paper uses base editor mutagenesis to identify activating DNMT3A mutations, revealing hyperactivating variants in the ADD domain that remain functional in the presence of a heterozygous R882H mutation.

bioRxiv · Apr 12, 2023Biochemistry

Base editor scanning charts the DNMT3A activity landscape

N. Z. Lue, E. M. Garcia, K. C. Ngan, C. Lee, J. G. Doench, B. B. Liau

The paper uses base editing and a DNA methylation reporter to scan DNMT3A mutations, identifying functional perturbations and revealing a noncanonical DNA affinity role for the PWWP domain.

bioRxiv · Apr 12, 2022Biochemistry