W. K. Lieberman

Base Editor Scanning Reveals Activating Mutations of DNMT3A

The paper uses base editor mutagenesis to identify activating DNMT3A mutations, revealing hyperactivating variants in the ADD domain that remain functional in the presence of a heterozygous R882H mutation.

Chemoproteomics yields a selective molecular host for acetyl-CoA

The paper develops a chemoproteomics-based method to selectively detect acetyl-CoA using a Nanoluc-NAA50 fusion protein and a ligand displacement assay.