TFAM Dependent Mitochondrial Fitness Limits CD8⁺ T Cell Immunopathology and Sustains Protective Immunity during Viral Pneumonia
Zahrasadat Navaeiseddighi, Kai Guo, SYED SAUD HASAN, Zhihan Wang, Rutuparnna Mishra, Taylor Schmit, Jamanah Ahsan, Emily J Moser, Junguk Hur, Jacob S. Yount, Ramkumar Mathur, Liang Zhou, Nadeem Khan
This study shows that reduced mitochondrial fitness in CD8 T cells, caused by TFAM insufficiency, leads to increased immunopathology during viral pneumonia and impaired protective immunity.
bioRxiv · Oct 22, 2026 · PreprintImmunology