Author

Zahrasadat Navaeiseddighi

University of FloridaORCID 0000-0002-4300-9748Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Jamanah Ahsan· 2 shared Junguk HuriD· 2 shared Kai GuoiD· 2 shared Ramkumar MathuriD· 2 shared Taylor SchmitiD· 2 shared Emily J Moser· 1 shared Jacob S. YountiD· 1 shared Liang ZhouiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Jamanah Ahsan

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 22, 2026

TFAM Dependent Mitochondrial Fitness Limits CD8⁺ T Cell Immunopathology and Sustains Protective Immunity during Viral Pneumonia

Zahrasadat Navaeiseddighi, Kai Guo, SYED SAUD HASAN…·Nadeem Khan

This study shows that reduced mitochondrial fitness in CD8 T cells, caused by TFAM insufficiency, leads to increased immunopathology during viral pneumonia and impaired protective immunity.

DOI 10.64898/2026.09.24.754254

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 25, 2025

NF-κB driven inflammation mediates loss of upper airway epithelial tolerance to Streptococcus pneumoniae during influenza co-infection

Zahrasadat Navaeiseddighi, Zhihan Wang, Kai Guo…·M. Nadeem Khan

This study shows that influenza co-infection disrupts epithelial tolerance to Streptococcus pneumoniae via NF-κB driven inflammation, leading to bacterial invasion and highlighting TRAF6-NF-κB as a therapeutic target.

2 citations

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