Jamanah Ahsan

TFAM Dependent Mitochondrial Fitness Limits CD8⁺ T Cell Immunopathology and Sustains Protective Immunity during Viral Pneumonia

This study shows that reduced mitochondrial fitness in CD8 T cells, caused by TFAM insufficiency, leads to increased immunopathology during viral pneumonia and impaired protective immunity.

NF-κB driven inflammation mediates loss of upper airway epithelial tolerance to Streptococcus pneumoniae during influenza co-infection

This study shows that influenza co-infection disrupts epithelial tolerance to Streptococcus pneumoniae via NF-κB driven inflammation, leading to bacterial invasion and highlighting TRAF6-NF-κB as a therapeutic target.