Junguk Hur

TFAM Dependent Mitochondrial Fitness Limits CD8⁺ T Cell Immunopathology and Sustains Protective Immunity during Viral Pneumonia

This study shows that reduced mitochondrial fitness in CD8 T cells, caused by TFAM insufficiency, leads to increased immunopathology during viral pneumonia and impaired protective immunity.

Schema-Grounded Multitask Instruction Fine-tuning for Joint Biomedical Named Entity Recognition and Relation Extraction in Pharmacovigilance

This paper fine-tunes large language models for joint biomedical named entity recognition and relation extraction, achieving improved performance across multiple tasks and datasets.

Ignet 2.0 and Vignet: An Ontology-Driven Web Platform for Biomedical Gene Interaction Discovery and Visualization

Ignet 2.0 and Vignet provide ontology-driven platforms for gene interaction discovery, vaccine network analysis, and AI-assisted knowledge retrieval from biomedical literature.

VO: The Vaccine Ontology

The paper introduces the Vaccine Ontology (VO), a standardized framework for representing vaccines and related data, enhancing data integration and AI research.

SEA CDM: Study-Experiment-Assay Common Data Model and Databases for Cross-Domain Data Integration and Analysis

The paper introduces a common data model and databases for integrating heterogeneous biomedical data, enabling cross-domain analysis and revealing sex-specific immune response insights.

NF-κB driven inflammation mediates loss of upper airway epithelial tolerance to Streptococcus pneumoniae during influenza co-infection

This study shows that influenza co-infection disrupts epithelial tolerance to Streptococcus pneumoniae via NF-κB driven inflammation, leading to bacterial invasion and highlighting TRAF6-NF-κB as a therapeutic target.

Regional interneuron transcriptional changes reveal pathologic markers of disease progression in a mouse model of Alzheimer's disease

The paper identifies transcriptional changes in interneurons across Alzheimer's disease stages in mice, revealing disease progression markers and potential therapeutic targets.

Ontology-based Protein-Protein Interaction Explanation Using Large Language Models

This study uses large language models and ontologies to extract and explain protein-protein interactions from scientific literature, showing improved performance with parameter-efficient fine-tuning.

Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach

The paper identifies three key effects of Casiopeina II-gly treatment using pathway analysis and network theory, showing perturbation of signaling and metabolic pathways and activation of immune responses.