Author

Naila S. Ashraf

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

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Organism:mouse· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1

Frequent Co-Authors

Maria do Carmo CostaiD· 5 shared Ana F. FerreiraiD· 2 shared Emily D. Shaw· 2 shared Gülin ÖziD· 2 shared Hayley S. McLoughliniD· 2 shared Henry Lauris PaulsoniD· 2 shared Anna Camós‐CarrerasiD· 1 shared Anna J. Barget· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersNeuroscience

Maria do Carmo CostaORCID

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5 papers

Recent·Most cited

Tissue-specific vulnerability to apoptosis in Machado-Joseph disease

Ana F. Ferreira, Mafalda Raposo, Emily D. Shaw, Naila S. Ashraf, Filipa Medeiros, M. Fátima Brilhante, Matthew Perkins, João Vasconcelos, Teresa Taylor Kay, Maria do Carmo Costa, Manuela Caroline Ferreira Lima

The paper assesses apoptosis-related gene expression in MJD patients and mice to identify potential biomarkers and tissue-specific apoptosis vulnerability.

Cells · May 17, 2023Peer-reviewedNeuroscience

Blood neurofilament light chain levels are associated with disease progression in a transgenic SCA3 mouse model

David Mengel, Isabel G. Wellik, Kristen H. Schuster, Sabrina I. Jarrah, Madeleine Wacker, Naila S. Ashraf, Gülin Öz, Matthis Synofzik, Maria do Carmo Costa, Hayley S. McLoughlin

The paper measures blood neurofilament light chain (NfL) levels in a transgenic SCA3 mouse model and finds they correlate with disease progression and severity.

bioRxiv · Feb 28, 2023 · PreprintNeuroscience

Altered retinal structure and function in Spinocerebellar ataxia type 3

Vasileios Toulis, Ricardo Pedro Casaroli-Marano, Anna Camós‐Carreras, Marc Figueras‐Roca, Bernardo F. Sánchez-Dalmau, Esteban Muñoz, Naila S. Ashraf, Ana F. Ferreira, Naheed Wali Khan, Gemma Marfany, Maria do Carmo Costa

This study investigates retinal structure and function in SCA3 patients and transgenic mice, finding correlations between retinal changes and disease severity.

Neurobiology of Disease · May 21, 2022Peer-reviewedNeuroscience

In vivo molecular signatures of cerebellar pathology in spinocerebellar ataxia type 3

Maria do Carmo Costa, Maria Radzwion, Hayley S. McLoughlin, Naila S. Ashraf, Svetlana Fischer, Vikram G. Shakkottai, Patrı́cia Maciel, Henry Lauris Paulson, Gülin Öz

The paper identifies neurochemical biomarkers of SCA3 pathology in mouse models and shows their reversibility with ATXN3 reduction.

Movement Disorders · Jul 4, 2020Peer-reviewedNeuroscience

Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia Type 3 disease protein

Naila S. Ashraf, Joanna R. Sutton, Yemen Yang, Bedri Ranxhi, Kozeta Libohova, Emily D. Shaw, Anna J. Barget, Sokol V. Todi, Henry Lauris Paulson, Maria do Carmo Costa

The paper identifies 15 druggable genes that modulate ATXN3 levels and toxicity in SCA3, with FBXL3/SCF pathway showing potential as a therapeutic target.

Neurobiology of Disease · Nov 26, 2019Peer-reviewedNeuroscience