Author

David Mengel

German Center for Neurodegenerative DiseasesORCID 0000-0002-4133-7182Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Matthis SynofzikiD· 3 shared Madeleine Wacker· 2 shared Alexandra DürriD· 1 shared Ammar Al‐ChalabiiD· 1 shared Andrew N. BayneiD· 1 shared Benjamin DannenmanniD· 1 shared Claire EwenczykiD· 1 shared Cyril GoizetiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Matthis SynofzikORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders

Mehrdad A. Estiar, Eric Yu, Parizad Varghaei, Jay P. Ross, Setareh Ashtiani, Andrew N. Bayne, Giulia Coarelli, Dagmar Timmann, Thomas Klockgether, Danique Beijer, David Mengel, Marie Coutelier, Patrick A. Dion, Oksana Suchowersky, Claire Ewenczyk, , Ziv Gan‐Or

This study identifies digenic inheritance of SPG7 and AFG3L2 mutations as a cause of motor neuron and cerebellar disorders in 17 patients.

BMC Medicine · Mar 24, 2026Peer-reviewedGenetic & Genomic Medicine

Most L1CAM is not associated with extracellular vesicles in human biofluids and iPSC-derived neurons

Vaibhavi Kadam, Madeleine Wacker, Patrick Oeckl, Milena Korneck, Benjamin Dannenmann, Julia Skokowa, Stefan Hauser, Markus Otto, Matthis Synofzik, David Mengel

The paper validates EV isolation from multiple biofluids using orthogonal methods but finds L1CAM does not reliably enrich for neuron-derived EVs.

Molecular Neurobiology · Apr 10, 2025Peer-reviewedNeuroscience

Blood neurofilament light chain levels are associated with disease progression in a transgenic SCA3 mouse model

David Mengel, Isabel G. Wellik, Kristen H. Schuster, Sabrina I. Jarrah, Madeleine Wacker, Naila S. Ashraf, Gülin Öz, Matthis Synofzik, Maria do Carmo Costa, Hayley S. McLoughlin

The paper measures blood neurofilament light chain (NfL) levels in a transgenic SCA3 mouse model and finds they correlate with disease progression and severity.

bioRxiv · Feb 28, 2023 · PreprintNeuroscience