The pre-mRNA Splicing Modulator Pladienolide B Inhibits Cryptococcus neoformans Germination and Growth
Sierra L. Love, Megan C. McKeon, Henrik Vollmer, Joshua C. Paulson, Nanami Oshimura, O. Millien Valentine, Sébastien C. Ortiz, Christina M. Hull, Aaron A. Hoskins
This study shows that pladienolide B inhibits Cryptococcus neoformans growth and spore germination, with enhanced efficacy when combined with FK506 or clorgyline.
mSphere · Jun 23, 2025Peer-reviewedMicrobiology