A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators
Sierra L. Love, Henrik Vollmer, Ya‐Chu Chang, Joshua C. Paulson, Tucker J. Carrocci, Melissa S. Jurica, Hai Dang Nguyen, Aaron A. Hoskins
This paper develops a yeast-based high-throughput screening platform to identify small molecules modulating pre-mRNA splicing, identifying 4 compounds and showing one affects splicing in cancer cells with a splicing factor mutation.
ACS Chemical Biology · Jan 12, 2026Peer-reviewedBiochemistry