Author

Joshua C. Paulson

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:yeast· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Aaron A. HoskinsiD· 3 shared Henrik Vollmer· 2 shared Sierra L. LoveiD· 2 shared Christina M. HulliD· 1 shared Hai Dang NguyeniD· 1 shared Megan C. McKeoniD· 1 shared Melissa S. JuricaiD· 1 shared Nanami Oshimura· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

Aaron A. HoskinsORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators

Sierra L. Love, Henrik Vollmer, Ya‐Chu Chang, Joshua C. Paulson, Tucker J. Carrocci, Melissa S. Jurica, Hai Dang Nguyen, Aaron A. Hoskins

This paper develops a yeast-based high-throughput screening platform to identify small molecules modulating pre-mRNA splicing, identifying 4 compounds and showing one affects splicing in cancer cells with a splicing factor mutation.

ACS Chemical Biology · Jan 12, 2026Peer-reviewedBiochemistry

Control of 3' Splice Site Selection in S. cerevisiae by a Highly Conserved Amino Acid within the Prp8 α-finger Domain

Ye Liu, Joshua C. Paulson, Aaron A. Hoskins

This study shows that a specific amino acid in the Prp8 protein influences 3' splice site selection in yeast by interacting with the -3 pyrimidine of the 3SS, affecting splicing efficiency and 3SS competition.

RNA · Oct 30, 2025Peer-reviewedBiochemistry

The pre-mRNA Splicing Modulator Pladienolide B Inhibits Cryptococcus neoformans Germination and Growth

Sierra L. Love, Megan C. McKeon, Henrik Vollmer, Joshua C. Paulson, Nanami Oshimura, O. Millien Valentine, Sébastien C. Ortiz, Christina M. Hull, Aaron A. Hoskins

This study shows that pladienolide B inhibits Cryptococcus neoformans growth and spore germination, with enhanced efficacy when combined with FK506 or clorgyline.

mSphere · Jun 23, 2025Peer-reviewedMicrobiology