Modular mRNA platform for in vivo antigen-specific immune tolerance
Shota Imai, Naoto Nishida, Ryo Maeno, Ayano Ikebuchi, Hitoshi Sasatsuki, Risa Saito, Kazutaka Matoba, Sadahiro Iwabuchi, Tomohiro Iba, Hisamichi Naito, Kanto Nagamori, Toan Van Le, Iriya Fujitsuka, Makie Ueda, Rikinari Hanayama, Tomoyoshi Yamano
This paper introduces Tol-mRNA, a modular mRNA platform that induces antigen-specific immune tolerance by delivering PD-L1 and TGF-β along with antigen, showing therapeutic benefits in murine models and human immune settings.
bioRxiv · May 21, 2026 · PreprintImmunology