ImmunologybioRxivPreprint
Modular mRNA platform for in vivo antigen-specific immune tolerance
Shota Imai, Naoto Nishida, Ryo Maeno…·Tomoyoshi Yamano
This paper introduces Tol-mRNA, a modular mRNA platform that induces antigen-specific immune tolerance by delivering PD-L1 and TGF-β along with antigen, showing therapeutic benefits in murine models and human immune settings.