Massively parallel in vivo Perturb-seq reveals cell type-specific transcriptional networks in cortical development
Xinhe Zheng, Boli Wu, Yuejia Liu, Sean Simmons, Kwanho Kim, Grace S. Clarke, Abdullah Ashiq, Joshua C. Park, Jiwen Li, Zhilin Wang, Liqi Tong, Wang Qizhao, Keerthi Thirtamara Rajamani, Rodrigo Muñoz-Castañeda, Shang Mu, , Xin Jin
This study develops a high-throughput in vivo Perturb-seq platform to analyze gene function across diverse cell types in the brain and peripheral nervous system, identifying cell type-specific transcriptional networks.
Cell · May 20, 2024Peer-reviewedNeuroscience