Kwanho Kim

This study integrates long-read WGS and single-nucleus RNA-seq to identify structural variants affecting gene expression in Parkinson's disease with cell type resolution.

This paper develops an in vivo multiomic Perturb-seq platform to improve gRNA recovery and applies it to study neurodevelopmental disorder risk genes in the cortex.

This study identifies AKAP11's role in regulating lipid metabolism and neuronal support in astrocytes, linking its dysfunction to schizophrenia and bipolar disorder risk.

This study develops a high-throughput in vivo Perturb-seq platform to analyze gene function across diverse cell types in the brain and peripheral nervous system, identifying cell type-specific transcriptional networks.

This study shows that microglia mediate fetal brain transcriptional responses to maternal inflammation, highlighting their role in neurodevelopmental outcomes.

The paper identifies neuron-class specific signals that drive differential myelination across cortical layers using single-cell data from mouse neocortex.

The paper investigates how PTEN heterozygous mutations affect different cell types in human cortical organoids and shows that these effects lead to abnormal circuit activity regardless of genetic background.

The paper presents a single-cell multiomics atlas of human cortical organoid development, revealing molecular programs of cellular diversification and identifying human-specific gene roles in lineage establishment.

The paper identifies human-specific enrichment of schizophrenia risk genes in callosal neurons of the developing neocortex using comparative transcriptomic analysis across species and developmental stages.

This study uses human brain organoids to show that ASD risk genes cause accelerated development of specific cortical neuron classes.

This study identifies temporally divergent regulatory mechanisms in neuronal development and maturation across mouse and marmoset neocortex.