Author

Grace S. Clarke

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Boli WuiD· 2 shared Jiwen LiiD· 2 shared Joshua Z. LeviniD· 2 shared Sean SimmonsiD· 2 shared Xin JiniD· 2 shared Xinhe ZhengiD· 2 shared Abdullah Ashiq· 1 shared Alan Chau· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Boli WuORCID

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2 papers

Recent·Most cited

Concordant transcriptional and morphological remodeling revealed by in vivo Perturb-CLEAR

Boli Wu, Sean Simmons, Seoyeon Kim, Jiwen Li, Masood A. Akram, Chang Sin Park, Xinhe Zheng, Iain Mendez, Sasha Patel, Alan Chau, Nadia Burciu, Pranay Dayal, Thokozile Nyasulu, Nhan Huynh, Grace S. Clarke, , Xin Jin

The paper develops Perturb-CLEAR to study dendritic morphogenesis in the developing mouse cortex, revealing gene-specific multimodal phenotypes linked to NDD risk genes.

bioRxiv · Apr 8, 2026 · PreprintNeuroscience

Massively parallel in vivo Perturb-seq reveals cell type-specific transcriptional networks in cortical development

Xinhe Zheng, Boli Wu, Yuejia Liu, Sean Simmons, Kwanho Kim, Grace S. Clarke, Abdullah Ashiq, Joshua C. Park, Jiwen Li, Zhilin Wang, Liqi Tong, Wang Qizhao, Keerthi Thirtamara Rajamani, Rodrigo Muñoz-Castañeda, Shang Mu, , Xin Jin

This study develops a high-throughput in vivo Perturb-seq platform to analyze gene function across diverse cell types in the brain and peripheral nervous system, identifying cell type-specific transcriptional networks.

Cell · May 20, 2024Peer-reviewedNeuroscience