Jiwen Li

Concordant transcriptional and morphological remodeling revealed by in vivo Perturb-CLEAR

The paper develops Perturb-CLEAR to study dendritic morphogenesis in the developing mouse cortex, revealing gene-specific multimodal phenotypes linked to NDD risk genes.

In vivo multiomic Perturb-seq with enhanced nuclear gRNA capture

This paper develops an in vivo multiomic Perturb-seq platform to improve gRNA recovery and applies it to study neurodevelopmental disorder risk genes in the cortex.

Massively parallel in vivo Perturb-seq reveals cell type-specific transcriptional networks in cortical development

This study develops a high-throughput in vivo Perturb-seq platform to analyze gene function across diverse cell types in the brain and peripheral nervous system, identifying cell type-specific transcriptional networks.

Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis

This study identifies Prdm16 and Vcam1 as regulators of postnatal radial glia disappearance and the termination of cortical neurogenesis.

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

The paper compares gene expression and stress responses in human and mouse astrocytes, finding conserved and divergent features that may explain differences in disease models.