Enhancer adoption by an LTR retrotransposongenerates viral-like particles causingdevelopmental limb phenotypes
Juliane Glaser, Giulia Cova, Beatrix Fauler, Cesar A. Prada‐Medina, Virginie Stanislas, Mai H.Q. Phan, Robert Schöpflin, Yasmin Aktas, Martin Franke, Guillaume Andrey, Natalia Bartzoka, Christina Paliou, Verena Laupert, Wing-Lee Chan, Lars Wittler, , Stefan Mundlos
The paper shows that activation of an LTR retrotransposon in the embryo leads to viral-like particle production, causing limb malformations through apoptotic cell death.
Nature Genetics · Jul 1, 2025Peer-reviewedDevelopmental Biology