PROX1 loss in adult mouse Schlemm's canal causes permanent ocular hypertension
Sofia Lara Ochoa, Hoi‐Lam Li, Hyeohn Kim, Zihang Yan, Natalia C Mendonca, Pan Liu, Hyunjoo Jean Lee, Michael P. Vincent, Sultan Almunif, Hao F. Zhang, Haiyan Gong, Evan Alexander Scott, Mark Johnson, Benjamin R. Thomson
This study shows that loss of PROX1 in adult mouse Schlemm's canal leads to permanent ocular hypertension by converting the canal to a vein-like phenotype.
JCI Insight · May 5, 2026Peer-reviewedPhysiology